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Wiad Lek. 2022;75(4 pt 1):781-786. doi: 10.36740/WLek202204106.
OBJECTIVE: The aim: The aim of the study is to evaluate the clinical and laboratory characteristics of the course of COVID-19 pneumonia, the diagnostic significance of laboratory methods for detecting the SARS-CoV-2 virus on the based on a retrospective analysis.
PATIENTS AND METHODS: Materials and methods: We studied the case histories of 96 patients who were treated at the municipal non-profit enterprise “Lviv Clinical Emergency Care Hospital” for the period from 07/01/2020 to 07/31/ 07/2020 with a diagnosis of pneumonia, which corresponded to 5 points on the CO-RADS scale. We analyzed clinical and laboratory signs of COVID-19 pneumonia based on Quantitative Reverse Transcription Polymerase Chain Reaction (RT-qPCR) test results to SARS-CoV-2 infection (a positive RT- qPCR was observed in the first group and negative – in the second group).
RESULTS: Results: In the two groups, no clinical difference in disease progression was found. The most common symptoms of coronavirus pneumonia were found with the same frequency in patients with a laboratory-confirmed diagnosis and without one. A positive PCR test in nasopharyngeal and oropharyngeal swabs was detected more often in testing for up to 10 days, in patients over 60, and in severe cases of COVID-19.
CONCLUSION: Conclusions: The diagnosis of COVID-19 pneumonia should be based on a combination of clinical, biological and radiological signs of this disease. A negative PCR test result does not exclude the diagnosis of coronavirus disease. Test results are influenced by the time of sampling, the severity of the disease and the age of the patients.